|Flow Cytometry (Flow)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1/IgG2a|
|Immunogen||T-acute lymphoblastic leukemia (T-ALL) cells and FMY9S5 cells containing the CD33 gene|
|Conjugate||FITC , PE|
|Storage buffer||PBS with 0.2% carrier protein|
|Contains||0.08% sodium azide|
|Storage conditions||4° C, do not freeze|
This antibody is a monoclonal mixture of FITC-conjugated CD7 (clone MG34, isotype IgG2a) and PE-conjugated CD33 (clone FOS, isotype IgG1).
CD7 is a 40kD transmembrane, single-chain glycoprotein. CD7 is expressed by majority of peripheral blood T cells, NK cells and all Thymocytes. The presence or absence of CD7 is a useful marker for the classification of T- and NK-cell malignancies. The CD7 molecule is absent in a subset of human T cells under certain physiologic conditions. Thus an increase in CD7 negative T cells can be seen in some inflammatory skin disease. CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. The protein is also expressed on, and is a useful marker for, peripheral monocytes. It is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD33; CD33 antigen (gp67); CD33 molecule transcript; CD7; CD7 antigen (p41); FLJ00391; GP40; gp67; LEU-9; Myeloid cell surface antigen CD33; p41 protein; sialic acid binding Ig-like lectin 3; Sialic acid-binding Ig-like lectin 3; SIGLEC-3; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41
Gene Aliases: CD33; CD7; GP40; LEU-9; p67; SIGLEC-3; SIGLEC3; Tp40; TP41
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule membrane-bound signaling molecule myelin protein receptor signaling molecule structural protein
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