|Flow Cytometry (Flow)||0.2 µg/10^6 cells|
|Tested Species reactivity||Mouse|
|Host / Isotype||Mouse / IgG2b, kappa|
|Immunogen||Mouse CD72.1 (Lyb-2.1).|
|Contains||0.1% sodium azide|
|Storage conditions||4° C|
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
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