|Flow Cytometry (Flow)||1.0 ug/10^6 cells|
|Miscellaneous PubMed (MISC)||See 6 publications below|
|ELISA (ELISA)||See 1 publications below|
|Tested Species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2b|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage conditions||4° C, do not freeze|
MA5-17607 targets CD8a/T subset NK in FACS applications and shows reactivity with Mouse samples.
The MA5-17607 immunogen is mouse thymocytes.
This antibody recognizes CD8. CD8 is composed of an alpha chain with Mr=30-34 kDa linked by disulfide bonds to a beta chain with Mr=30-32 kDa. In addition to forming heterodimers with the beta chain, the alpha chain is also capable of forming homodimers while the beta chain is incapable of forming homodimers. The extracellular portion of CD8alpha binds to the non-polymorphic portion of MHC class I molecules. This interaction is important in the antigen presentation to CD8+ T cells. The cytoplasmic domain of the alpha chain associates with p56lck, a member of the Src family of tyrosine kinases. Cells which are reactive with this antibody include: thymocytes, natural killer cells, and a subset (CD4-) of peripheral T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD8; CD8a; Leu-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); MAL; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2
Gene Aliases: BB154331; Cd8a; Ly-2; Ly-35; Ly-B; Lyt-2; Lyt2
UniProt ID: (Mouse) P01731
Entrez Gene ID: (Mouse) 12525
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