|Flow Cytometry (Flow)||6 ug/ml|
|Functional Assay (FN)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay-Dependent|
|Flow Cytometry (Flow)||See 1 publications below|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Tested Species reactivity||Dog, Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Armenian hamster / IgG2|
|Immunogen||CD80-transfected CHO cell line|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage conditions||4° C, do not freeze|
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activation B7-1 antigen; B7; B7 protein; B7-1; B7-1 protein; B7.1; Cd28l; CD28LG; CD28LG1; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); LAB7; Ly-53; Ly53; MIC17; T-cell co-stimulatory protein B7-1; T-lymphocyte activation antigen CD80; TS/A-1
Gene Aliases: B7; B71; Cd28l; Cd80; Ly-53; Ly53; MIC17; TSA1
UniProt ID: (Mouse) Q00609
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