|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 129 and 413 of Human CDC23|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29218 targets CDC23 in IF and WB applications and shows reactivity with Human samples.
The PA5-29218 immunogen is recombinant fragment corresponding to a region within amino acids 129 and 413 of Human CDC23.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ANAPC8; anaphase promoting complex subunit 8; Anaphase-promoting complex subunit 8; APC8; cell division cycle 23 homolog; Cell division cycle protein 23 homolog; CUT23; Cyclosome subunit 8
Gene Aliases: ANAPC8; APC8; CDC23; CUT23
UniProt ID: (Human) Q9UJX2
Entrez Gene ID: (Human) 8697
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