|Flow Cytometry (Flow)||1.2 ug/10^6 cells|
|Immunohistochemistry (Frozen) (IHC (F))||1-2 ug/10^6 cells|
|Western Blot (WB)||4 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||CEA partially purified from a perchloric acid extract from liver metastases of colonic tumors.|
|Storage buffer||PBS, pH 7.2|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody recognizes native human CEACAM1, 5 protein expressed in transfected mammalian cells.
Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 5; CD66a; CD66a antigen; CD66e; CEA; Meconium antigen 100; pan CEACAM
Gene Aliases: BGP; BGP1; BGPI; CD66e; CEA; CEACAM1; CEACAM5
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein immunoglobulin receptor superfamily kinase membrane-bound signaling molecule protein kinase receptor signaling molecule transferase G-protein coupled receptor hydrolase immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.