|Flow Cytometry (Flow)||1 ug/10^6 cells|
|Immunohistochemistry (Frozen) (IHC (F))||1 ug/10^6 cells|
|Western Blot (WB)||4 ug/ml|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||CEA partially purified from a perchloric acid extract from liver metastases of colonic tumors.|
|Storage buffer||PBS, pH 7.2|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody recognizes native human CEACAM1, 5, 6, 8 protein expressed in transfected mammalian cells.
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. The CEA family proteins belong to the immuno-globulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen; Carcinoembryonic antigen CGM6; carcinoembryonic antigen gene family member 6; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); Carcinoembryonic antigen-related cell adhesion molecule 8; CD66a; CD66a antigen; CD66b; CD66c; CD66e; CD67; CD67 antigen; CEA; CGM6; Cluster of Differentiation 66c; Meconium antigen 100; NCA; Non-specific cross-reacting antigen NCA-95; Non-specific crossreacting antigen; Normal cross-reacting antigen; pan CEACAM
Gene Aliases: BGP; BGP1; BGPI; CD66b; CD66c; CD66e; CD67; CEA; CEACAM1; CEACAM5; CEACAM6; CEACAM8; CEAL; CGM6; NCA; NCA-95
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein immunoglobulin receptor superfamily kinase membrane-bound signaling molecule protein kinase receptor signaling molecule transferase G-protein coupled receptor hydrolase immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase
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