|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with rat based on sequence homology.
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AGAP-2; ANK repeat and PH domain-containing protein 2; ANK repeat and PH domains 2; Arf GAP with GTP-binding protein-like; Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2; arf-GAP with GTPase; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin; centaurin, gamma 1; Centaurin-gamma-1; CENTG1; Cnt-g1; gamma 1; GGAP2; GTP-binding and GTPase activating protein 2; GTP-binding and GTPase-activating protein 2; Phosphatidylinositol 3-kinase enhancer; phosphatidylinositol-3-kinase enhancer; phosphoinosi; phosphoinositide 3-kinase enhancer; PIKE
Gene Aliases: AGAP-2; AGAP2; CENTG1; cnt-g1; GGAP2; KIAA0167; mKIAA0167; PIKE
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