|Western Blot (WB)||0.03-0.1 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (NTQAAQKLKDKE) corresponding to the internal amino acids of CES1|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACAT; acyl coenzyme A:cholesterol acyltransferase; Acyl-coenzyme A:cholesterol acyltransferase; Brain carboxylesterase hBr1; Carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); carboxylesterase 2 (liver); CE-1; CEH; CES1; CES2; cholesteryl ester hydrolase; Cocaine carboxylesterase; Egasyn; HMSE; HMSE1; human monocyte/macrophage serine esterase 1; liver carboxylesterase; Liver carboxylesterase 1; Methylumbelliferyl-acetate deacetylase 1; MGC117365; Monocyte/macrophage serine esterase; monocyte/macrophage serine-esterase 1; PCE-1; REH; Retinyl ester hydrolase; Serine esterase 1; SES1; TGH; Triacylglycerol hydrolase
Gene Aliases: ACAT; CE-1; CEH; CES1; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH
UniProt ID: (Human) P23141
Entrez Gene ID: (Human) 1066
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