|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 213 of Human CHMP2B|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29007 targets CHMP2B in IF and WB applications and shows reactivity with Human samples.
The PA5-29007 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 213 of Human CHMP2B.
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Charged multivesicular body protein 2b; CHMP2.5; CHMP2b; chromatin modifying protein 2B; Chromatin-modifying protein 2b; DMT1; Vacuolar protein sorting-associated protein 2-2; vacuolar protein-sorting-associated protein 2-2; VPS2 homolog B; VPS2-2; VPS2B
Gene Aliases: ALS17; CGI-84; CHMP2.5; CHMP2B; DMT1; VPS2-2; VPS2B
UniProt ID: (Human) Q9UQN3
Entrez Gene ID: (Human) 25978
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