|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide, KLH conjugated.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-32702 detects CHRM2 from human samples.
PA1-32702 has been successfully used in immunohistochemistry (paraffin tissue) applications.
The PA1-32702 immunogen is Synthetic peptide, KLH conjugated.
Muscarinic cholinergic receptor 2 is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 7TM receptor; acetylcholine receptor, muscarinic 2; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, isoform a; FLJ43243; HM2; MGC120006; MGC120007; Muscarinic acetylcholine receptor M2; muscarinic M2 receptor
Gene Aliases: CHRM2; HM2
UniProt ID: (Human) P08172
Entrez Gene ID: (Human) 1129
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