|ChIP assay (ChIP)||5-7 ug|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Raised against recombinant CIITA protein.|
|Contains||<0.1% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats) and a GTP binding domain. It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. CIITA also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: acid domain containing; C2TA; CIITA; CIITAIV; leucine rich repeat and acid domain containing; MHC class II transactivator; MHC class II transactivator type I; MHC class II transactivator type III; MHC2TA; NLR family; NLR family, acid domain containing; NLRA; nucleotide-binding oligomerization domain; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
Gene Aliases: C2TA; CIITA; CIITAIV; MHC2TA; NLRA
UniProt ID: (Human) P33076
Entrez Gene ID: (Human) 4261
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