|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Western Blot (WB)||See 2 publications below|
|Tested Species reactivity||Human, Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 219 and 478 of Human COL1A1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol, 1% BSA|
|Contains||0.025% Proclin 300|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29569 targets COL1A1 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-29569 immunogen is recombinant fragment corresponding to a region within amino acids 219 and 478 of Human COL1A1.
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha-1 chain; alpha-1 type 1 collagen; Alpha-1 type I collagen; alpha1(I) procollagen; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; collagen of skin; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; OI4; pro-alpha-1 collagen type 1; procollagen, type I, alpha 1; tendon and bone; type I proalpha 1; type I procollagen alpha 1 chain
Gene Aliases: Col1a-1; COL1A1; Cola-1; Cola1; EDSC; Mov-13; Mov13; OI1; OI2; OI3; OI4
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