|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 552 and 826 of Human COL6A1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29068 targets COL6A1 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-29068 immunogen is recombinant fragment corresponding to a region within amino acids 552 and 826 of Human COL6A1.
The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha 1 (VI) chain (61 AA); alpha-1 polypeptide; Collagen alpha-1(VI) chain; collagen VI; collagen VI, alpha-1 polypeptide; collagen, type VI, alpha 1; OPLL; procollagen, type VI, alpha 1
Gene Aliases: AI747156; BTHLM1; Col6a-1; COL6A1; OPLL; UCHMD1
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