|Western Blot (WB)||1:100-1:2000|
|Tested Species reactivity||Fruit fly, Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide of residues 239-250, which is a 100% conserved region of human, mouse, rat and Drosophila Alien.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Suggested positive control: antigen standard for COPS2 (transient overexpression lysate).
TRIP15 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP. TRIP15 is also involved in early stage of neuronal differentiation via its interaction with NIF3L1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ALIEN; Alien homolog; Alien protein; alien-like; alien-PA; alien-PB; alien-PD; alien-PE; CG9556-PA; CG9556-PB; CG9556-PD; CG9556-PE; COP9 (constitutive photomorphogenic) homolog, subunit 2; COP9 complex homolog subunit 2; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; CSN2; d-Alien; Dch2; drosophila COP9 signalosome homolog 2; JAB1-containing signalosome subunit 2; SGN2; signalosome subunit 2; thyroid receptor interacting protein 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15; TRIP15; tyroid receptor interacting protein 15
Gene Aliases: AI315723; ALIEN; BcDNA:LD10463; C85265; CG9556; CH2; COPS2; CSN2; DCH2; Dmel\CG9556; Dmel_CG9556; SGN2; TRIP-15; TRIP15
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