|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||1/500 - 1/2000|
|Immunocytochemistry (ICC)||See 1 publications below|
|Tested Species reactivity||Chicken, Mouse, Sheep, Rat|
|Published species reactivity||Rabbit|
|Host / Isotype||Goat / IgG|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
Predicted to react with all mammals based on sequence homology.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: COX-1; cyclooxygenase 3; Cyclooxygenase-1; PGH synthase 1; PGHS-1; PHS 1; prostaglandin endoperoxide synthase; Prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1, prostaglandin G/H synthase 1; PTGS1
Gene Aliases: COX-1; Cox-3; COX1; Cox3; PGHS-1; Pghs1; PHS 1; PTGS1
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.