|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 222 and 469 of CSE1L|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. [provided by RefSeq].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; CSE1; CSE1 chromosome segregation 1 like; CSE1 chromosome segregation 1-like; CSE1 chromosome segregation 1-like yeast; Exp2; Exportin-2; Importin-alpha re-exporter; XPO2
Gene Aliases: 2610100P18Rik; AA407533; Capts; CAS; CSE1; CSE1L; XPO2
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