|Immunohistochemistry (Frozen) (IHC (F))||Assay-Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:250|
|Tested Species reactivity||Human, Mouse, Pig, Rat, Xenopus, Zebrafish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide of C-terminal region of human CTR1.|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris citrate/tris phosphate, pH 7-8|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
Suggested positive control: human breast cancer and kidney tissue.
The trace metal copper (Cu) plays a crucial role in mammalian cells as a cofactor for many enzymes. Cu-related genetic diseases, such as Menkes disease and Wilson disease, arise from a lack of Cu homeostasis in mammalian cells. CTR1 is a high-affinity copper-uptake protein. The C-terminal domain is similar to the Raf family of protein kinases, but it's first two-thirds encodes a novel protein domain. CTR1 provides the primary avenue for copper uptake in mammalian cells, thereby, affecting Cu homeostasis and embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: copper transport 1 homolog; Copper transporter 1; Copper uptake transporter 1; COPT1; CTR1; hCTR1; high affinity copper uptake protein; High affinity copper uptake protein 1; Liver regeneration-related protein LRRGT00200; rCTR1; solute carrier family 13 (sodium/sulphate symporters), member 1; solute carrier family 31 (copper tansporters) member 1; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1; Solute carrier family 31 member 1
Gene Aliases: 4930445G01Rik; AI787263; AU016967; COPT1; ctr-1; CTR1; LRRGT00200; SLC31A1; Xctr1; zgc:76839
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