|Immunohistochemistry (Paraffin) (IHC (P))||1:300|
|Western Blot (WB)||1:500|
|Tested Species reactivity||Human, Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to residues T E E M G S G D Y D S M K E P C F R E E N A N F N K C of human CXCR4.|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M potassium phosphate, pH 7.2, with 0.14M NaCl|
|Storage conditions||-20°C or -80°C if preferred|
PA1-21626 detects CXCR4 in human and rat samples.
PA1-21626 has been successfully used in ELISA, immunohistochemistry (FFPE), and Western blot procedures. Suggested positive controls for this product are human peripheral blood cells or sections of human spleen cells.
The PA1-21626 immunogen is a synthetic peptide corresponding to residues T E E M G S G D Y D S M K E P C F R E E N A N F N K C of human CXCR4.
The C-X-C chemokines contain a pair of cysteine residues separated by a single amino acid. These chemokines function as chemo-attractants for neutrophils. Receptors for the C-X-C family include IL-8RA (also known as CXCR-1), IL-8RB (also called CXCR-2), CXCR-3 and fusin (LESTR or CXCR-4). Fusin has been identified as the major co-receptor for HTLV and HIV-1; and SDF-1 has been shown to inhibit HIV-1 infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-X-C chemokine receptor type 4; CD184; CD184 antigen; chemokine (C-X-C motif) receptor 4; chemokine receptor; chemokine receptor (LCR1); CXC chemokine receptor; CXC-R4; CXCR-4; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide-associated protein 3; LPS-associated protein 3; neuropeptide Y receptor Y3; neuropeptide Y3 receptor; NPY3R; NPYR; NPYRL; NPYY3R; SDF-1 receptor; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor; WHIM
Gene Aliases: CD184; CXCR4; D2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM; WHIMS
UniProt ID: (Human) P61073
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor
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