|Flow Cytometry (Flow)||1:20|
|Western Blot (WB)||1:4000-1:6000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||COOH-terminal amino acids of mouse CXCR7 (347–362) SRVSETEYSALEQNTK coupled to KLH.|
|Storage buffer||whole serum|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA3-069 detects CXC Chemokine Receptor Type 7 from human and mouse samples.
PA3-069 has been successfully used in Western blot and immunocytochemistry procedures. By Western blot, this antibody detects a 42 kDa protein corresponding to mouse CXC Chemokine Receptor Type 7.
The PA3-069 antigen is the COOH-terminal amino acids of mouse CXCR7 (347–362) SRVSETEYSALEQNTK coupled to KLH.
C-X-C chemokine receptor type 7 (CXCR-7) is a protein member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it was considered to be an orphan receptor, because its endogenous ligand has not been identified. It is now classified as a chemokine receptor able to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; chemokine; chemokine (C-X-C motif) receptor 7; Chemokine orphan receptor 1; CXC-R7; CXCR-7; G protein-coupled receptor; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
Gene Aliases: ACKR3; AW541270; CMKOR1; CXC-R7; CXCR-7; CXCR7; GPR159; RDC-1; RDC1
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor
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