|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 119 and 415 of Human CYP21A2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29441 targets CYP21A2 in WB applications and shows reactivity with Human samples.
The PA5-29441 immunogen is recombinant fragment corresponding to a region within amino acids 119 and 415 of Human CYP21A2.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 21-OHase; CA21H; CAH1; congenital adrenal hyperplasia); CPS1; CYP21; CYP21B; Cytochrome P-450c21; cytochrome P450; Cytochrome P450 21; Cytochrome P450 XXI; cytochrome P450, family 21, subfamily A, polypeptide 2; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2; Cytochrome P450-C21; Cytochrome P450-C21B; P450c21B; polypeptide 2; steroid 21 hydroxylase; Steroid 21-hydroxylase; steroid 21-monooxygenase; subfamily XXIA (steroid 21-hydroxylase
Gene Aliases: CA21H; CAH1; CPS1; CYP21; CYP21A2; CYP21B; P450c21B
UniProt ID: (Human) P08686
Entrez Gene ID: (Human) 1589
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