|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 257-285 amino acids from the central region of human CYP2C19|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within its gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYP2C19; CYPIIC17; CYPIIC19; cytochrome P-450 II C; Cytochrome P450 2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; Cytochrome P450-11A; Cytochrome P450-254C; flavoprotein-linked monooxygenase; mephenytoin 4'-hydroxylase; Mephenytoin 4-hydroxylase; microsomal monooxygenase; P450-11A; P450-254C; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
Gene Aliases: CPCJ; CYP2C; CYP2C19; CYPIIC17; CYPIIC19; P450C2C; P450IIC19
UniProt ID: (Human) P33261
Entrez Gene ID: (Human) 1557
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.