|Immunohistochemistry (Paraffin) (IHC (P))||6 - 14 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 20 amino acid peptide from 3rd extracellular domain of human CYSLTR1 / CYSLT1.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%) Rabbit, Guinea pig (85%) Bovine, Elephant, Horse, Pig (80%).
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cys-leukotriene-1 receptor; Cys-LT1 receptor; CysLT(1); CYSLT1; CYSLT1R; CYSLTR; CYSLTR1; Cysteinyl leukotriene D4 receptor; Cysteinyl leukotriene receptor 1; Cysteinyl lt1 receptor; G-protein coupled receptor HG55; HG55; HMTMF81; LTD4 receptor
Gene Aliases: CYSLT1; CYSLT1R; CYSLTR; CYSLTR1; HMTMF81
UniProt ID: (Human) Q9Y271
Entrez Gene ID: (Human) 10800
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