|Immunohistochemistry (Paraffin) (IHC (P))||2.5-5.0 µg/ml|
|Tested Species reactivity||Bovine, Dog, Chicken, Human, Mouse, Non-human primate, Rat, Xenopus|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide from the C-terminal end of chicken N-cadherin|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
PA5-16481 targets Cadherin Pan in IHC (P) applications and shows reactivity with mouse, Non-human primate, Rat, Xn, Bovine, Canine, Chicken, and Human samples. This antibody recognizes Cadherin E, N, P and R (Cadherin 1, 2, 3 and 4).
The PA5-16481 immunogen is a synthetic peptide from the C-terminal end of chicken N-cadherin.
Cadherins are calcium dependent cell adhesion molecules, which play important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. They are expressed in tissue specific mannerand and are required for assembly of cells into solid tissue. Individual cadherin molecules are known to co-operate with each other to form a linear cell adhesion zipper. In adhesion junctions cadherins are bound to Beta and gamma catenins which in turn bind to alpha catenin, an actin binding protein. Cadherins play important part in tumor invasion and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin 15, M-cadherin (myotubule); cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, P-cadherin (placental); cadherin 3, type 1, P-cadherin (placental); cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; calcium-dependent adhesion protein; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDw325; cell-CAM 120/80; E-Cadherin; E-cadherin (epithelial); E-cadherin 1; epithelial; Epithelial cadherin; L-CAM; Liver cell adhesion molecule; liver cell adhesion protein; N-cadherin; N-cadherin 1; Neural cadherin; P-cadherin; Placental cadherin; R-CAD; R-cadherin; retina cadherin; Retinal cadherin; RPE-specific cadherin; Uvomorulin; xTCAD-1
Gene Aliases: AA960649; AI385538; Arc-1; AW120700; BOS_17031; BOS_17249; BOS_22126; CAD4; Cadherin-1; Cadp; CD324; CD325; CDH1; CDH15; CDH2; CDH3; CDH4; Cdh4l; CDHE; CDHN; CDHP; CDw325; E-cad; ECAD; HJMD; L-CAM; LCAM; N-cadherin; NCAD; P-cadherin; PCAD; R-CAD; R-Cadh; R-cadherin; RCAD; Um; UVO; Uvomorulin
UniProt ID: (Dog) F1PAA9, (Bovine) Q6R8F2, (Human) P12830, (Chicken) P08641, (Human) P19022, (Chicken) P10288, (Human) P22223, (Bovine) P19535, (Human) P55283, (Chicken) P24503, (Rat) Q9R0T4, (Mouse) P09803, (Mouse) P15116, (Rat) Q9Z1Y3, (Mouse) P10287, (Mouse) P39038, (Xenopus) P30944
Entrez Gene ID: (Dog) 442858, (Bovine) 282637, (Human) 999, (Chicken) 415860, (Human) 1000, (Bovine) 281062, (Chicken) 414745, (Human) 1001, (Bovine) 281063, (Human) 1002, (Chicken) 419222, (Rat) 83502, (Mouse) 12550, (Mouse) 12558, (Rat) 83501, (Mouse) 12560, (Mouse) 12561, (Rat) 114588, (Xenopus) 100337618
Molecular Function: cadherin
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