|ELISA (ELISA)||Assay Dependent|
|Radioimmune Assays (RIA)||Assay dependent|
|Tested Species reactivity||Chemical|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Chemical / Small Molecule- Caffeine 3 conjugated to KLH.|
|Storage buffer||PBS, pH 7.4, with 40% glycerol|
|Contains||0.1% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA1-91822 detects Caffeine from various samples.
MA1-91822 has been successfully used in radioimmune assay applications.
The MA1-91822 immunogen is Chemical / Small Molecule- Caffeine 3 conjugated to KLH.
Caffeine is a methylxanthine alkaloid found in the seeds, nuts, or leaves of a number of plants native to South America and East Asia that is structurally related to adenosine and acts primarily as an adenosine receptor antagonist with psychotropic and anti-inflammatory activities. Upon ingestion, caffeine binds to adenosine receptors in the central nervous system (CNS), which inhibits adenosine binding. This inhibits the adenosine-mediated downregulation of CNS activity; thus, stimulating the activity of the medullary, vagal, vasomotor, and respiratory centers in the brain. This agent also promotes neurotransmitter release that further stimulates the CNS. The anti-inflammatory effects of caffeine are due the nonselective competitive inhibition of phosphodiesterases (PDEs). Inhibition of PDEs raises the intracellular concentration of cyclic AMP (cAMP), activates protein kinase A, and inhibits leukotriene synthesis, which leads to reduced inflammation and innate immunity. [National Center for Biotechnology Information. PubChem Compound Database; CID=2519]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1,3,7-Trimethylxanthine; C8H10N4O2; Guaranine; Methyltheobromine
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