|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 203 of Human Caldesmon|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27719 targets Caldesmon in WB applications and shows reactivity with Human samples.
The PA5-27719 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 203 of Human Caldesmon.
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Caldesmon; CDM; H-CAD; HCAD; L-CAD; NAG22; testis secretory sperm-binding protein Li 227n
Gene Aliases: CAD; CALD1; CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
UniProt ID: (Human) Q05682
Entrez Gene ID: (Human) 800
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