|Immunohistochemistry (IHC)||10 µg/mL|
|Immunoprecipitation (IP)||5 µg|
|Western Blot (WB)||0.5-2 µg/mL|
|Western Blot (WB)||See 4 publications below|
|Miscellaneous PubMed (MISC)||See 2 publications below|
|Tested Species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat , Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (PEHKTSDSTFLVFMSHGIREG) corresponding to amino acids 129-149 of human Caspase-1, coupled to KLH.|
|Storage buffer||0.1M tris glycine, pH 7.4, with 0.15M NaCl|
|Contains||0.05% sodium azide|
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis (1). The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1/ICE (IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: apoptosis-related cysteine peptidase interleukin 1; beta; CASP-1; CASP1 nirs variant 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase-1; convertase; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; IL1B-convertase; IL1BC; interleukin 1; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; P45
Gene Aliases: CASP1; ICE; IL1BC; IL1BCE; P45
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