|Immunohistochemistry (IHC)||10 µg/ml|
|Western Blot (WB)||0.5-1 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant human Clusterin isoform 1|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
This antibody reacts with Clusterin isoform 1.
A suggested positive control is human brain tissue lysate.
Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer and quote;s b-amyloid peptide. Clusterin expression is increased in Alzheimer and quote;s disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression. Clusterin exists in at least two distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AAG4, APO-J, APOJ, CLI, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2; Aging-associated gene 4 protein; aging-associated protein 4; Apo-J; Apolipoprotein J; CLI; Clusterin; Complement cytolysis inhibitor; complement lysis inhibitor; Complement-associated protein SP-40,40; Ku70-binding protein 1; NA1/NA2; sulfated glycoprotein 2; Testosterone-repressed prostate message 2; TRPM-2
Gene Aliases: AAG4; APO-J; APOJ; CLI; CLU; CLU1; CLU2; KUB1; NA1/NA2; SGP-2; SGP2; SP-40; TRPM-2; TRPM2
UniProt ID: (Human) P10909
Entrez Gene ID: (Human) 1191
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