|ELISA (ELISA)||Assay dependent|
|Western Blot (WB)||2 ug/mL|
|Flow Cytometry (Flow)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Complement C3 purified from human plasma.|
|Storage buffer||HEPES with 0.15M NaCl, 0.01% BSA, 50% glycerol|
|Contains||0.03% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
A suggested positive control for this product is human plasma.
Human Complement C3 (C3) is synthesized as a single-chain pro-molecule (185kDa) that then suffers several post-translational modifications. Before being secreted as a mature protein, C3 is split into b-chain (645 residues and 70kDa) and a-chain (992 residues and 115 kDa) and forms a rare internal thioester bond. C3 plays a central role in the activation of all the three pathways of complement activation i.e. the classical, alternative, and lectin pathway. As C3 is the major complement component and participates in several stages of the immune response, its deficiency generally associated with higher susceptibility to severe bacterial infections and in some cases with autoimmune diseases such as systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acylation Stimulating Protein Cleavage Product; acylation-stimulating protein cleavage product; C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a anaphylatoxin; Complement C3; complement component C3a; complement component C3b; epididymis secretory sperm binding protein Li 62p; prepro-C3
Gene Aliases: AHUS5; ARMD9; ASP; C3; C3a; C3b; CPAMD1; HEL-S-62p
UniProt ID: (Human) P01024
Entrez Gene ID: (Human) 718
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