|ELISA (ELISA)||Assay Dependent|
|Immunoprecipitation (IP)||1 µl|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Protein purified from Human plasma|
|Purification||Ammonium sulfate precipitation|
|Storage buffer||HEPES with 0.15M NaCl, 0.01% BSA, 50% glycerol|
|Contains||0.03% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
A suggested positive control for this product is human plasma.
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: acidic C4; Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C4; C4A anaphylatoxin; C4A2; C4A3; C4A4; C4A6; C4S; CO4; Complement C4-A; CPAMD2; DAMC-258G8.6; MGC164979; MHC class III region complement; RG; Rodgers form of C4
Gene Aliases: C4; C4A; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; CPAMD2; RG
UniProt ID: (Human) P0C0L4
Entrez Gene ID: (Human) 720
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