|Western Blot (WB)||1:1000|
|Tested Species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the C-terminal region of rat GJA1 conjugated to KLH|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with chicken, canine, finch, human, mouse, non-human primate, sheep, Xenopus and zebrafish based on 100% sequence homology.
This antibody is specific for ~43 kDa Connexin43 protein.
Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of Connexin43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of Connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: connexin 43; Connexin-43; CX43; DFNB38; Gap junction 43 kDa heart protein; Gap junction alpha-1 protein; gap junction membrane channel protein alpha 1; GJA1; Oculodentodigital dysplasia; ODDD; SDTY3; Syndactyly type III
Gene Aliases: Cx43; Cxn-43; Gja1
UniProt ID: (Rat) P08050
Entrez Gene ID: (Rat) 24392
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