|Western Blot (WB)||0.01-0.03 µg/ml|
|Tested Species reactivity||Bovine, Dog, Human, Mouse, Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids WKASAGHAVSIA of Human Cortactin|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-31469 detects Cortactin from human samples.
PA1-31469 has been successfully used in Western blot applications.
The PA1-31469 immunogen is: Synthetic peptide - amino acids WKASAGHAVSIA of Human Cortactin
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1110020L01Rik; Amplaxin; CORTACTIN; Cttn; EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); Oncogene EMS1; Src substrate cortactin
Gene Aliases: 1110020L01Rik; BOS_25081; CTTN; Cttnb; EMS1
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