|Radioimmune Assays (RIA)||1:100|
|Tested Species reactivity||Chemical|
|Host / Isotype||Donkey / IgG|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
Cross-reactivity is as follows: Cortisol 100%, Prednisolone 38%, Cortisone 23%, 11-Deoxycortisol 2.5%, 17a-OHP 0.4%, and Corticosterone <0.1%.
Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.