|Gel Shift (GS)||Assay Dependent|
|Immunoprecipitation (IP)||1 ug|
|Western Blot (WB)||1-2 ug/ml|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2b, kappa|
|Immunogen||This antibody was prepared against full-length, recombinant, human cyclin E protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CCNE; CCNE1; G1/S-specific cyclin E1; G1/S-specific cyclin-E1
Gene Aliases: CCNE; CCNE1; pCCNE1
UniProt ID: (Human) P24864
Entrez Gene ID: (Human) 898
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.