|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:12.5-25|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Western Blot (WB)||See 2 publications below|
|Immunocytochemistry (ICC)||See 2 publications below|
|Immunohistochemistry (IHC)||See 5 publications below|
|Tested Species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat , Marsupial , Human Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein encoding NBF2 domain of human CFTR|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage conditions||4° C|
MA5-11768 targets Cystic Fibrosis Transmembrane Regulator in IF, IHC (P), IP, and WB applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-11768 immunogen is recombinant protein encoding NBF2 domain of human CFTR.
CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; ATP-binding cassette, subfamily c, member 7; cAMP-dependent chloride channel; CFTR; Channel conductance-controlling ATPase; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7
Gene Aliases: ABC35; ABCC7; AW495489; CF; CFTR; CFTR/MRP; dJ760C5.1; MRP7; RGD1561193; TNR-CFTR
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