|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the C-terminal region of human Cytochrome P450 11B1/2|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008].
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Protein Aliases: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; CPN1; CYP11B; CYPXIB1; CYPXIB2; Cytochrome P-450Aldo; Cytochrome P-450c11; Cytochrome P-450C18; cytochrome P450; cytochrome P450 11B1; Cytochrome P450 11B1, mitochondrial; Cytochrome P450 11B2, mitochondrial; cytochrome p450 XIB1; cytochrome P450, family 11, subfamily B, polypeptide 1; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; Cytochrome P450C11; FHI; mitochondrial; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P450C11; polypeptide 1; Steroid 11-beta-hydroxylase; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo; subfamily XIB (steroid 11-beta-hydroxylase)
Gene Aliases: ALDOS; CPN1; CPN2; CYP11B; CYP11B1; CYP11B2; CYP11BL; CYPXIB2; FHI; P-450C18; P450aldo; P450C11; P450C18; S11BH
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