|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the internal region of human Cytochrome P450 3A4/5|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1,8-cineole 2-exo-monooxygenase; Albendazole monooxygenase; Albendazole sulfoxidase; aryl hydrocarbon hydroxylase; Cholesterol 25-hydroxylase; CP33; CP34; CYP3A; CYP3A3; CYP3A5; CYPIIIA3; CYPIIIA4; CYPIIIA5; cytochrome P450; Cytochrome P450 3A3; Cytochrome P450 3A4; Cytochrome P450 3A5; Cytochrome P450 HLp; Cytochrome P450 HLp2; Cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; Cytochrome P450-PCN1; Cytochrome P450-PCN3; flavoprotein-linked monooxygenase; glucocorticoid-inducible P450; HLp2; microsomal monooxygenase; NF-25; Nifedipine oxidase; P450-III; P450-III, steroid inducible; P450-PCN3; P450C3; P450PCN1; polypeptide 3; Quinine 3-monooxygenase; steroid inducible; subfamily; subfamily IIIA (niphedipine oxidase); Taurochenodeoxycholate 6-alpha-hydroxylase; xenobiotic monooxygenase
Gene Aliases: CP33; CP34; CP35; CYP3A; CYP3A3; CYP3A4; CYP3A5; CYPIIIA3; CYPIIIA4; CYPIIIA5; HLP; NF-25; P450C3; P450PCN1; P450PCN3; PCN3
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