|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 239 and 553 of Human Cytokeratin 6A|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28235 targets Cytokeratin 6 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28235 immunogen is recombinant protein fragment corresponding to a region within amino acids 239 and 553 of Human Cytokeratin 6A.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CK-6A; CK-6D; CK6A; CK6C; CK6D; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin-6A; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; epidermal type II; K6A; K6D; kamp-keratin derived antimicrobial peptide; KDAMP; keratin; keratin 6A, , type II; keratin 6A, type II; keratin K6h; keratin, epidermal type II, K6A; Keratin, type II cytoskeletal 6A; Keratin-6A; keratin-6C; KRT6C; KRT6D; type II cytoskeletal 6A; type-II keratin Kb12; Type-II keratin Kb6
Gene Aliases: CK-6C; CK-6E; CK6A; CK6C; CK6D; K6A; K6C; K6D; KRT6A; KRT6C; KRT6D; PC3
UniProt ID: (Human) P02538
Entrez Gene ID: (Human) 3853
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