|Western Blot (WB)||1:5000|
|Tested Species reactivity||Bovine, Dog, Human, Mouse, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (50 RMDETEIRSFFARYG 64) of DAZL protein.|
|Storage buffer||whole serum with 50% glycerol|
|Contains||0.025% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA5-23152 targets DAZL in WB applications and shows reactivity with Bovine, Canine, Human, mouse, new world monkey and chimpanzee samples.
Protein expression pattern show that DAZL is involved in mitosis and meiosis of human germ cell. The DAZL gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females .The protein is expressed in germ cells of diverse mammalian species. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In humans, DAZL is expressed in primordial germ cells, adult testis, and the ovary. It plays a central role during spermatogenesis. Defects in DAZL may cause infertility due to severe oligozoospermia (az) and non obstructive azoospermia. The concentrations of DAZL transcripts were lower in men with spermatogenic failure. Drosophila and mouse mutants that have lost DAZ homologous gene function found to be azoospermic, just as with human azoospermia DAZ. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAZ homolog; DAZ-like autosomal; DAZH; DAZL1; DAZLA; Deleted in azoospermia-like; Deleted in azoospermia-like 1; deleted in azoospermia-like protein; germline specific RNA binding protein; spermatogenesis gene on the Y-like autosomal; SPGY-like-autosomal; SPGYLA; testis secretory sperm-binding protein Li 204a
Gene Aliases: BOS_1495; Daz-like; DAZH; DAZL; DAZL1; DAZLA; SPGYLA; Tpx-2; Tpx2
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.