|Flow Cytometry (Flow)||Neat-1:5|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Immature myeloid monocyte-derived dendritic cells (MDDCs)|
|Storage buffer||PBS with 1% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred, store in dark|
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
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Protein Aliases: C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; CD209; CD209 antigen; CD209a; CDSIGN; CIRE; DC-SIGN; Dcsign; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; HIV gpl20-binding protein; MGC130443; SIGN-R1; SIGNR5
Gene Aliases: CD209; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1
UniProt ID: (Human) Q9NNX6
Entrez Gene ID: (Human) 30835
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