|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 1 and 126 of Human DCTN3|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30437 targets DCTN3 in WB applications and shows reactivity with Human samples.
The PA5-30437 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 126 of Human DCTN3.
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DCTN-22; DCTN22; DCTN3; dynactin 3; dynactin 3 (p22); Dynactin complex subunit 22 kDa subunit; dynactin light chain; Dynactin subunit 3; p22
Gene Aliases: DCTN-22; DCTN22; DCTN3
UniProt ID: (Human) O75935
Entrez Gene ID: (Human) 11258
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