|Western Blot (WB)||1:100-1:500|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide CYFRSEASEWEPNAISF conjugated to KLH, corresponding to amino acids 304-320 of Human DDR2 (Accession Q16832).|
|Contains||0.09% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-31993 detects DDR2 from human samples.
PA1-31993 has been successfully used in ELISA and Western blot applications.
The PA1-31993 immunogen is synthetic peptide CYFRSEASEWEPNAISF conjugated to KLH, corresponding to amino acids 304-320 of Human DDR2 (Accession Q16832).
Suggested postive control is HL60 cell lysate
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD167 antigen-like family member B; CD167b; cell migration-inducing protein 20; Discoidin domain receptor 2; discoidin domain receptor family, member 2; Discoidin domain-containing receptor 2; Discoidin domain-containing receptor tyrosine kinase 2; hydroxyaryl-protein kinase; MIG20a; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; Neurotrophic tyrosine kinase, receptor-related 3; NTRKR3; Receptor protein-tyrosine kinase TKT; RP11-572K18.1; TKT; TYRO10; Tyrosine-protein kinase TYRO10; tyrosylprotein kinase
Gene Aliases: DDR2; MIG20a; NTRKR3; TKT; TYRO10
UniProt ID: (Human) Q16832
Entrez Gene ID: (Human) 4921
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