|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 469 and 699 of Human DDX23|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30312 targets DDX23 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-30312 immunogen is recombinant fragment corresponding to a region within amino acids 469 and 699 of Human DDX23.
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 100 kDa U5 snRNP-specific protein; DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; DEAD box protein 23; Probable ATP-dependent RNA helicase DDX23; prp28; PRP28 homolog; PRP28 homolog, yeast; PRP28p homolog; PRPF28; U5 snRNP 100 kD protein; U5-100K; U5-100KD; yeast
Gene Aliases: 3110082M05Rik; 4921506D17Rik; DDX23; prp28; PRPF28; SNRNP100; U5-100K; U5-100KD
UniProt ID: (Human) Q9BUQ8
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