|Flow Cytometry (Flow)||Neat-1:10|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rat / IgG2b|
|Immunogen||Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1|
|Storage buffer||PBS with 1% BSA, 5% sucrose|
|Contains||0.09% sodium azide|
|Storage conditions||4° C, store in dark, DO NOT FREEZE!|
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
Once reconstituted, this product has a shelf life of approx. 18 months.
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: beta-glucan receptor; BGR, Clecsf12, beta-GR,C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; dectin-1; dendritic cell-associated C-type lectin 1
Gene Aliases: beta-GR; BGR; Clecsf12
Entrez Gene ID: (Mouse) 56644
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