|Immunohistochemistry (Paraffin) (IHC (P))||1:20-1:200|
|Immunoprecipitation (IP)||Assay dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Mouse / IgG1|
|Clone||SMAC 17 1-87|
|Immunogen||C-Terminal His tagged recombinant human Smac/DIABLO.|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA1-936 detects Smac/DIABLO from human, mouse and rat tissues.
MA1-936 has been successfully used in Immunoprecipitation, Western blot, Immunohistochemistry (paraffin), Immunofluorescence and immunocytochemistry. By Western blot it detects a 25-kDa band representing Smac/DIABLO.
MA1-936 antigen is C-term His tagged recombinant human Smac/DIABLO.
Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is a protein that is released from the mitochondria into the cytosol as a response to apoptic stimuli. It enables apoptosis by neutralizing the inhibitory effect of inhibitor of apoptosis proteins (IAP's). Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Diablo homolog, mitochondrial; diablo, IAP-binding mitochondrial protein; diablo-like protein; Direct IAP Binding Protein with Low pI; Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; SMAC
Gene Aliases: 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; SMAC
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