|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 32 and 124 of Human DUSP12|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28960 targets DUSP12 in WB applications and shows reactivity with Human samples.
The PA5-28960 immunogen is synthetic peptide corresponding to a region within amino acids 32 and 124 of Human DUSP12.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dual specificity protein phosphatase 12; Dual specificity tyrosine phosphatase YVH1; DUSP1; serine/threonine specific protein phosphatase; YVH1; YVH1 protein-tyrosine phosphatase ortholog
Gene Aliases: DUSP1; DUSP12; YVH1
UniProt ID: (Human) Q9UNI6
Entrez Gene ID: (Human) 11266
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