|Immunoprecipitation (IP)||5 ug/ml|
|Western Blot (WB)||1 ug/ml|
|Tested Species reactivity||Mouse|
|Host / Isotype||Sheep / IgG|
|Immunogen||residues 399-555 of mouse disabled GST fusion protein.|
|Purification||Ammonium sulfate precipitation|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
A suggested positive control for this product is 293 cells transfected with Dab-1 HA tag.
Disruption of Dab1 results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. DAB1 acts downstream of reelin in a signalling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AI956902; C630028C02Rik; Disabled homolog 1; RP23-356E21.1; scm; scr; scrambler; yot; yotari
Gene Aliases: AI956902; C630028C02Rik; Dab1; scm; scr; scrambler; yot
UniProt ID: (Mouse) P97318
Entrez Gene ID: (Mouse) 13131
Molecular Function: signaling molecule
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