|Immunohistochemistry (Paraffin) (IHC (P))||10 ug/ml|
|Western Blot (WB)||0.5-1 µg/ml|
|Tested Species reactivity||Chicken, Human, Mouse, Non-human primate, Rat, Xenopus, Zebrafish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (740 DTSEDEQSNYTTNC 753) of Dapper homolog 1 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Dapper homolog 1, an ortholog of Xenopus Dpr, antagonizes Wnt signaling by promoting Dvl degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism. Dapper homolog 1 acts as an interacting protein for Dvl, and the interaction is formed between the DEP (Dishevelled, Egl-10, and pleckstrin) domain of Dvl and the central and C-terminal regions of Dapper homolog 1. The gene for human Dapper homolog 1 is localized on chromosomal region 14q23.1. The protein impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. The protein is also required for normal notochord formation and is downregulated in hepatocellular carcinomas (HCC). It is expressed in human liver and various other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAPPER; dapper 1; dapper 1-A; Dapper antagonist of catenin 1; Dapper homolog 1; dapper homolog 1, antagonist of beta-catenin; dapper, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 1; DAPPER1; dapper1b; dishevelled-binding antagonist of beta-catenin 1; dishevelled-interacting protein; DPR1; FRODO; frodo 1; Frodo homolog; functional regulator of dsh in ontogenesis; HDPR1; Hepatocellular carcinoma novel gene 3 protein; heptacellular carcinoma novel gene 3; MDpr1; THYEX3; thymus expressed gene 3; Thymus-expressed novel gene 3 protein
Gene Aliases: 4921528D17Rik; AI115603; DACT1; DAPPER; DAPPER1; dpr; DPR1; Frd1; FRODO; Frodo1; HDPR1; HNG3; MDpr1; MTNG3; RGD1564008; THYEX3; XDpr; XDpr1b
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.