|Immunohistochemistry (Paraffin) (IHC (P))||Ready-to-use|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide mapping near the C-terminus of human desmin|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.6, with 1% BSA|
|Contains||<0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
This antibody is predicted to react with mouse and rat based on sequence homology.
A suggested positive control is skeletal muscle or sarcoma.
Desmin is a 53 kDa intermediate filament protein expressed in cardiac, skeletal, and smooth muscle cells, as well as lung tissue. In skeletal and cardiac muscle cells, desmin is localized at the Z-disk region and the intercalated disk. In smooth muscle tissue, desmin is expressed throughout the cells. During development, levels of desmin expression vary, being present at low levels in the early stages of myoblast replication and increasing during terminal differentiation. Unlike vimentin, desmin is expressed in both differentiating and mature muscle cells. Inhibiting desmin expression blocks myoblast fusion and myotube formation, suggesting that desmin is crucial during myogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CMD1I; CSM2; DES; Desmin; FLJ12025; intermediate filament protein; mutant desmin p.K241E
Gene Aliases: CSM1; CSM2; DES; LGMD2R
UniProt ID: (Human) P17661
Entrez Gene ID: (Human) 1674
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