|Immunohistochemistry (Paraffin) (IHC (P))||13 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 19 amino acid peptide from 3rd cytoplasmic domain of human DRD4 / Dopamine Receptor D4.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%) Gorilla (95%) Bovine, Pig (89%) Marmoset, Dog, Horse (84%).
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: D(2C) dopamine receptor; D(4) dopamine receptor; D4 dopamine receptor; D4DR; Dopamine 4 receptor; Dopamine D4 receptor; Dopamine receptor D4; DRD4; seven transmembrane helix receptor
Gene Aliases: D4DR; DRD4
UniProt ID: (Human) P21917
Entrez Gene ID: (Human) 1815
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